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Biochemistry classes for FMGE 2023 at Kings International Medical Academy

Biochemistry classes for FMGE 2023 at Kings International Medical Academy

Kings International Medical Academy is renowned as a leading coaching centre for FMGE, consistently achieving outstanding results. Our exceptional track record in FMGE speaks for itself and demonstrates our excellence. We are honoured to have Dr. V.S. Kumar, a highly esteemed faculty member, deliver an engaging lecture on the subject of Biochemistry at Kings International Medical Academy. Today, let’s delve into the topic of “Cholesterol Synthesis.”

                                                                   Cholesterol Synthesis

  • Cholesterol is Amphipathic in nature
  • 27c

Synthesis: occurs in all tissues- contain nucleated cells

Organs: Liver, Adrenal corlex, ovaries, testis

Organelle: SER/ Cytoplasm

Starting point: Acetyl COA

Regulation of Cholesterol Synthesis:

  1. Feedback inhibition: RLE- HMG-COA Reductase- Cholestrol & mevolonate (acts via sterol regulating element, binding protein)
  2. Hormonal Regulation:

Insulin & Thyroxine:

(dephosphorylated)

↑ Activity of RLE, + Chol. Syn.

Glucogon:

(phosphorylated)

↓ Activity of RLE, – Chol. Syn.

Cholesterol Synthesis:

HDL:

  1. tissue → Liver

Free cholesterol- active

Ester- storage

Reverse cholesterol transport:

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