Get an insight into Biochemistry with Kings’ FMGE coaching classes

Enroll in Kings International Medical Academy’s FMGE coaching classes and elevate your preparation for the Foreign Medical Graduate Examination (FMGE). With our comprehensive curriculum and experienced faculty, we provide targeted guidance to help you succeed in this crucial exam. Our interactive teaching methods, combined with personalized attention, ensure a deep understanding of the subjects and enhance your problem-solving skills. Join Kings International Medical Academy’s FMGE coaching classes to boost your confidence and increase your chances of clearing the exam with flying colours. In this blog, let’s learn more about the topic of biochemistry, which is handled by our esteemed faculty member, Dr. V.S. Kumar. Today, let’s focus on the topic ‘Collagen’.

Collagen

1) Most abundant protein in the body

2) Major structural protein in ECM

• Tropocollagen is the monomer unit
• Consist of 3 α chains – left hand structures but on combination right handed triple helix

Components:

Glycine residue, -OH proline & OH-lysine

Gly-x-y repeat

Synthesis:

Endoplasmic recticulum of fibroblast

Stage 1:

Formation of α-chains → Combine → Pre-pro-collagen

Stage 2:

Hydroxylation of Proline & Lusine

Glycosylation to OH- Lysine

Intracellular event- convert → Pre-pro-collagen → Procollagen

Extracellular event

Stage: Tropocollagen is formed

Types:

Type 1: Skin & bONE

Type 2: CarTWOlage

Type 3: ArTHREE

Type 4: Basemnet membrane floor

Disorders of Collagen:

Type 1:

• Osteogenesis Imperfecta aka Brittle bone d’s
• Osteoporosis
• Ehler danlos syndrome

Type 2:

Chondrodysplasia

Osteoarthritis

Type 3:

EDS

Type 4:

Good Pasteurs & Alports Syndrome

Scurvy → ATP-7x mutation

Menkes kinky hairs disease

Wilson’s (ATP-7B mutation)